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What is trazodone generic for "tricyclic antidepressants?" Tricyclic antidepressants (TCAs)—including trazodone—are in their class known as SSRIs (selective serotonin reuptake inhibitors, "commonly abbreviated," like SSRIs, as "SSRIs,") or SNRIs (norepinephrine reuptake inhibitors, "commonly abbreviated," like SNRs, as "SNRIs"), antidepressants that work by inhibiting the reabsorption (transporting back into body) of serotonin, a neurotransmitter that is often associated with emotional swings. (In the case of serotonergic antidepressants, drugs also affect a receptor for norepinephrine—the "reward" system.) With SSRIs, for example, many people experience both depression and mania, so these drugs are sometimes used "off-label," or in cases when other antidepressants have an unacceptable side effect profile. The current generic is not in the "off-label" category; it's used for the first treatment (depressives who are still depressive can be helped with trazodone. The generic is also being used in chronic MDD when other drugs aren't working much (more on this below). Trazodone has been on the shelves since 2006, so in my country it has a long history in generic form. (I've often wondered what other countries had to deal with!) The only other generic is generically similar, so one might assume that drug companies in those countries have a long history of trying to keep their drug on the shelves after it's approved but before available over the counter. There's a theory these companies have strong incentive to prevent generic drug approval and substitution, because the loss of profit in this case would be quite real. This is likely irrelevant from an economic perspective—if generics were widely available across Europe, the cost of drugs would probably drop significantly compared to the US, so profits in generic companies can be made at Lisinopril cost no insurance current prices. The generic manufacturers must file for is trazodone a generic drug a generic drug product approval (GPA), after generic approval, as the name needs another patent to protect from potential substitution (e.g. if a better drug that did not have patents is released, or if companies replace generic drugs with drugstore coupon code 10 off 60 new products of a similar formulation or structure, as was the case with Aspirin). Before FDA approval, drug companies must submit evidence that their drug is effective, acceptable, and not harmful to users: The Generic Application, in English. [PDF; about 22 pages] In some cases, though, drug companies may get the approval process expedited when there's no good drug comparator (as happens in people with severe mental illness), or in cases where drug approvals are a long process (e.g. the FDA's approval of antidepressants was almost 50 years ago). This has led some to speculate that drug companies are trying to give drugs even earlier approval by speeding up the standard FDA approval process. In cases when no comparator or faster drug approvals is possible (such as with people chronic psychiatric disorders), the FDA can approve drug without a comparative or faster approval. At this point, FDA has the right to make drug and say that all those taking it are not going to develop side effects. But of course, the side effects FDA can't approve are the ones people already have. So while FDA has the right, may often be wrong. In any case, generic drug approval can help the get on shelves much sooner than without it, and the availability of generic does in itself have some public safety benefit. However, patients may also take prescription drugs in place of generics—some do only require a prescription to be sold, but there might some people who, for inexplicable reason, want generic. To understand why, make sure you how generic drugs are approved. Generic drug approval processes are relatively straightforward. FDA requires generic partners to: Inform the FDA about how drug differs from the original and therefore not suitable for immediate sale the same condition Demonstrate it is equally well-suited for sale the same condition, without difference in labeling Sign a "statement of information" that explains: The drug's label The difference in packaging The difference in color formulations name For generic approval, this also includes: Designing and submitting a new label (to be approved the same way as original label) Rejected and approved plans, details on the Some medicines, like many blood plasma products red cells or tubes, are used much less than other medicines, and generic manufacturers have to submit medicines for review separately from that have more complex labeling requirements, where the generic has to show it is adequately labeled for an exact dosage and the dose.

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